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| Day 1: Monday 20 November | |||||
| Start | End | Type | Name | Title | |
| 08:30 | 09:00 | Registration | |||
| Welcome and opening Session Chair: Professor Simon Foote (ANU) |
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| 09:00 | 09:05 | Welcome: Professor Simon Foote | |||
| 09:05 | 09:15 | Introduction: Professor Brian Schmidt VC ANU | |||
| 09:15 | 9:50 | Opening | Alan Finkel (Australian Chief Scientist) | Genome engineering technologies in the Australian science landscape: progresses and challenges | |
| 9:50 | 10:30 | Morning Tea | |||
| Session 1: Revolutionising Cancer Research with CRISPR Session Chair: James Doecke (CSIRO) |
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| 10:30 | 11:00 | Invited | Pilar Blancafort (Harry Perkins Institiute, UWA) | Targeted epigenetic editing for reprograming of complex phenotypes in breast cancer | |
| 11:00 | 11:45 | Keynote | Laura Attardi (Stanford University, USA) |
Deconstructing the p53 Tumor Suppression Program Through Combined RNA interference and CRISPR Screening | |
| 11:45 | 12:15 | Invited | Susan Woods (University of Adelaide) | Rapid, complex models of colorectal cancer: using CRISPR/Cas9 genome editing to target frequently altered genes | |
| 12:15 | 12:30 | Selected talk | Shinsuke Mizutani (WEHI) | Whole genome in vivo CRISPR/Cas9 screens identify novel tumour suppressor genes in Eµ-Myc lymphomagenesis | |
| Sponsored Lunch session by Dharmacon
Session Chair: Kaylene Simpson (Petermac) |
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| 12:30 | 13:00 | Break | Lunch | ||
| 13:00 | 14:00 | Annaleen Vermeulen (Dharmacon) | Using CRISPR/Cas9 tools for gene knockout and transcriptional activation to understand gene function | ||
| Session 3: CRISPR/Cas9 advance editing techniques Session Chair: Denis Bauer (CSIRO) |
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| 14:00 | 14:30 | Organizer | Gaetan Burgio (ANU) | Improving HDR effciency for CRISPR/Cas9 editing in mice | |
| 14:30 | 14:45 | Selected talk | Andrew Kueh (WEHI) |
The application of CRISPR/Cas9 technology in generating complex mouse models |
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| 14:45 | 15:00 | Selected talk | Aidan O’Brien (CSIRO) | Predicting the HDR efficiency of CRISPR-Cas9 | |
| 15:00 | 15:20 | Break | Afternoon Tea | ||
| Session 4: Cohort level analysis using CRISPR/Cas9 editing Session Chair: Gaetan Burgio (ANU) |
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| 15:20 | 15:50 | Keynote | Danilo Maddalo (Novartis) | Crispr/Cas9 in in vivo modeling and drug discovery | |
| 15:50 | 16:20 | Organizer | Marco Herold (WEHI) | Using CRISPR/Cas9 to identify novel drug targets for cancer therapy | |
| 16:20 | 16:50 | Invited | Sean Grimmond (University of Melbourne) | Global cancer cohorts efforts | |
| 16:50 | 17:05 | Selected talk | Predrag Kalajdzic (CMRI) | The Vector and Genome Engineering Facility (VGEF): Customized service for your research needs | |
| 18:30 | Conference dinner Monday 20 November at the National Arboretum Canberra http://gingercatering.com.au/national-arboretum/ | ||||
| Day 2: Tuesday 21 November | |||||
| 08:30 09:00 Registration | |||||
| Session 5: Understanding and applying CRISPR/Cas9 Session Chair: Kaylene Simpson (Petermac) |
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| 09:00 | 09:15 | Selected talk | Nigel McMillian (Menzies Health Institute of Queensland) | Using of gene editing to treat cancers both in vitro and in vivo | |
| 09:15 | 09:45 | Organizer | Laurence Wilson (CSIRO) | Using machine learning to understand CRISPR-Cas9 activity | |
| 09:45 | 10:15 | Invited | Hugh Goold (Macquarie University) | Yeast 2.0: Design, synthesis, and testing of a Eukaryotic genome | |
| 10:15 | 10:30 | Organizer | James Doecke (CSIRO) |
What to expect from your CRIPSR experiment: Finding downstream effects adjacent to your primary target |
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| 10:30 | 10:50 | Break | Morning Tea | ||
| Session 6: CRISPR/Cas9 and Cancer Session Chair: Gaetan Burgio (ANU) |
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| 10:50 | 11:05 | Selected talk | Jai Rautela (WEHI) | Gene-editing in immune checkpoint discovery | |
| 11:05 | 11:20 | Selected talk | Andrew Jarratt (WEHI) | A whole genome CRISPR/Cas9 screen for regulators of JAK-STAT signalling reveals epigenetic control | |
| 11:20 | 11:35 | Selected talk | Jia-Nan Gon (WEHI) | Investigating the Resistant Mechanisms to the BCL2 selective inhibitor Venetoclax in Multiple Myeloma using Genome-Scale CRISPR/Cas9 Knockout Screening | |
| 11:35 | 11:50 | Selected talk | Mark van Delft (WEHI) | CRISPR/Cas9 screens reveal VDAC2 to be a critical regulator of BAX-mediated cell death and chemotherapeutic response | |
| 11:50 | 12:20 | Invited | Ross Hannan (ANU) | Genome wide screens to develop new targets for cancer therapy | |
| 12:20 | 13:20 | Lunch | |||
| Session 7: Show and Tell CRISPR/Cas9 Analysis Session Chair: Denis Bauer (CSIRO) |
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| 13:20 | 14:00 | Company pitches from: Millennium Science, Genesearch, Sigma, AGRF, Lonza, Scientifix, Biotools and Thermofisher | |||
| 14:00 | 14:15 | The Australian Phenomics Network (Dr Michael Dobbie, CEO) | |||
| Session 8: CRISPR/Cas9 Gene editing: Ethics and IP Session Chair: Laurence Wilson (CSIRO) |
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| 14:15 | 14:45 | Invited | Sally Davis (Davies, Collison and Cave IP) | CRISPR/Cas9: Innovation and Commercialisation in a Complex IP Environment | |
| 14:45 | 15:15 | Invited | Rachel Ankeny (University of Adelaide) | CRISPR/Cas9 and bioethics | |
| 15:15 | 15:35 | Break | Afternoon Tea | ||
| Session 9: Genome editing in model systems Session Chair: Marco Herold (WEHI) |
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| 15:35 | 16:05 | Invited | Yu Chang (BGI) |
Advancing genome editing technology adoption with computational innovations. |
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| 16:05 | 16:35 | Invited | Greg Neely (University of Sydney) | CRISPR/Cas9 high-throughput screening in Drosophila | |
| 16:35 | 17:05 | Invited | Leonie Quinn (ANU) | The inexplicable tumour suppressor behaviour of FUBP1 in Oligodendroglioma | |
| 18:00 | BBQ, Fellows Gardens, University House http://unihouse.anu.edu.au | ||||
| Day 3: Wednesday 22 November | |||||
| 08:30 09:00 Registration | |||||
| Session 10: High Throughput Screening and Beyond Genome Editing Session Chair: Denis Bauer (CSIRO) |
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| 9:00 | 9:30 | Invited | Ben Hayley (Genentech) | CRISPR/a screening and techniques | |
| 9:30 | 10:00 | Invited | Ryan Lister (Harry Perkins Institute) | Editing the epigenome | |
| 10:00 | 10:30 | Organizer | Kaylene Simpson (Peter McCallum, Meblourne) | High throughput screening strategies | |
| 10:30 | 10:50 | Break | Morning Tea | ||
| Session 11: Bioinformatics/Biostatistics approaches to data from CRISPR/Cas9 editing Session Chair: James Doecke (CSIRO) |
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| 10:50 | 11:35 | Keynote | Veera Baladandayuthapani (MD Anderson, USA) | Biostatistics for finding relevant targets | |
| 11:35 | 12:05 | Invited | Gordon Smyth (WEHI) | Using scRNA-seq to construct developmental lineage relationships in the mouse mammary gland | |
| 12:05 | 12:35 | Invited | Jean Yang (University of Sydney) | Data analysis for cancer research | |
| 12:35 | 12:50 | Closing remarks: Dr Denis Bauer (CSIRO) | |||