{"id":1773,"date":"2024-06-28T11:05:24","date_gmt":"2024-06-28T01:05:24","guid":{"rendered":"https:\/\/wp.csiro.au\/epws24\/?page_id=1773"},"modified":"2024-09-20T12:57:13","modified_gmt":"2024-09-20T02:57:13","slug":"health-implications-of-plastics-in-our-ecosystem","status":"publish","type":"page","link":"https:\/\/wp.csiro.au\/epws24\/health-implications-of-plastics-in-our-ecosystem\/","title":{"rendered":"Health implications of plastics in our ecosystem"},"content":{"rendered":"\n
Facilitated by\u00a0Professor Magdalena Plebanski<\/a>\u00a0(RMIT University)<\/h5>\n\n\n\n
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Professor Deborah Glass<\/a>\u00a0(Monash University)<\/p>\n<\/div><\/div>

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Pollution by nano and microplastics in the workplace and health<\/strong><\/h5>\n\n

Nanoparticles, defined as particles with a diameter less than 100 nm, can be inhaled and enter the body through the lungs. They can also enter the body through the skin or gastrointestinal tract, be transported in blood and the lymphatic system and bypass barriers within the body which are generally impermeable to larger particles. Further, substances adsorbed on the nanoparticles, can be delivered intracellularly or react with cell surface receptors, potentially initiating immune responses.<\/p>\n

Immunological effects of nano-sized particles including both inflammation and immunosuppression have been shown in many animal studies. Laboratory studies have shown that some nanoparticles can trigger the production of reactive oxygen species and cause damage to cell membranes and DNA. Nanoplastics have been found in human brains, hearts, lungs, breast milk, placenta and semen. Plastics vary in composition and can include toxic components, for example cadmium pigments are common in plastics. The effects of these nanoparticles on humans are unclear but likely to be variable and will be difficult to evaluate in humans.<\/p>\n\n

02_D1S2 Health Implications GLASS<\/a>Download<\/a><\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n\n\n
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Associate Professor Mayur Garg<\/a>\u00a0(Northern Health Hospital)<\/p>\n<\/div><\/div>

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Microplastics and human gut health<\/strong><\/h5>\n\n

Microplastics are ubiquitous in our environment, with evidence to date suggesting that humans ingest microplastics as part of our diet on a daily basis. The incidence and prevalence of multiple gastrointestinal illnesses has risen dramatically over the past 50 years, especially inflammatory bowel disease, disorders of gut-brain interaction, and gastrointestinal cancers. This presentation will discuss the potential link between microplastics and gut health, including putative effects on microbiota, gut immunology and inflammation.<\/p>\n\n

03_D1S2_A-1_Microplastics and Nanoplastics_GARG<\/a>Download<\/a><\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n\n\n
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Dr Kirsty Wilson<\/a>\u00a0(RMIT University)<\/p>\n<\/div><\/div>

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Nano and microparticles (polystyrene and silica) interactions with the immune system<\/strong><\/h5>\n\n

Nanoparticles come in many different shapes, sizes and compositions. This plethora of physicochemical properties affects how nanoparticles interact in biological environments, including with cells of the immune system. Solid polystyrene nanoparticles (PSNPs) in the viral\u00a0to bacterial\u00a0size range (40nm-1000nm) are an excellent model to study the impact of solid materials in the nano-micro range,\u00a0such as plastics,\u00a0on uptake\u00a0by immune cells as well as downstream effects on inflammation and the immune system in general.\u00a0PSNPs in the viral size range (40-100nm) by themselves\u00a0are rapidly taken up by activating immune cells such as dendritic cells, but\u00a0surprisingly\u00a0do not induce conventional inflammatory pathways. By themselves\u00a0these\u00a0viral sized PSNPs do not induce immune responses,\u00a0however\u00a0robust T and B cell responses\u00a0are\u00a0seen when\u00a0PSNPs\u00a0are used\u00a0as a vaccine delivery platform. Larger particles (500-1000nm), by themselves are\u00a0by contrast\u00a0taken up\u00a0preferentially\u00a0by\u00a0immune cells such a myeloid derived suppressor cells (MDSC) associated with the induction of immune-suppression.\u00a0This shows that small changes in the nano to micro scale for the size of solid man-made particles such as\u00a0PSNPs\u00a0have significant, unique and potentially divergent effects on the immune system.<\/p>\n\n

Presentation not available. Please contact the presenter directly.<\/em><\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n\n\n

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Professor Magdalena Plebanski<\/a>\u00a0(RMIT University)<\/p>\n<\/div><\/div>

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Polystyrene nano and microparticles interactions with the lung\u200b<\/strong><\/h5>\n\n

Airborne pollution is associated with inflammatory lung diseases such as asthma and chronic obstructive pulmonary disease\u00a0(<\/strong>COPD). Air pollution consists of both fine (~100-1000 nm) and ultrafine (less than 100 nm) particles. Ultrafine nanoparticles have been identified as a significant risk factor. Very little is known however about how diverse plastic and other man-made polymer nano and microparticles interact with the lung. We have studied the interaction of polystyrene nano and micro particles ranging from 40 nm to 1000 nm with immune cells that control inflammatory immune responses associated with asthma and COPD in the lung. Our studies in animal models show polystyrene particle size dependent effects on immunity and inflammation, and a surprising anti-inflammatory profile for a specific nanoparticle size range, capable of rendering lungs resistant to acute lung inflammation associated with asthma, while maintaining ability to clear viral infections such as influenza.<\/p>\n\n

05_D1S2_A_1_Polystyrene nano&microparticles interactions with lung_PLEBANSKI_<\/a>Download<\/a><\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n\n\n
<\/div>\n","protected":false},"excerpt":{"rendered":"

Facilitated by\u00a0Professor Magdalena Plebanski\u00a0(RMIT University)<\/p>\n","protected":false},"author":186,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"nba-redirect":"","footnotes":""},"class_list":["post-1773","page","type-page","status-publish","hentry"],"yoast_head":"\nEnding Plastic Waste Symposium 2024<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wp.csiro.au\/epws24\/health-implications-of-plastics-in-our-ecosystem\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Health implications of plastics in our ecosystem - Ending Plastic Waste Symposium 2024\" \/>\n<meta property=\"og:description\" content=\"Facilitated by\u00a0Professor Magdalena Plebanski\u00a0(RMIT University)\" \/>\n<meta property=\"og:url\" content=\"https:\/\/wp.csiro.au\/epws24\/health-implications-of-plastics-in-our-ecosystem\/\" \/>\n<meta property=\"og:site_name\" content=\"Ending Plastic Waste Symposium 2024\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-20T02:57:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/wp.csiro.au\/epws24\/files\/2024\/06\/Headshot_Deb_Glass.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/wp.csiro.au\\\/epws24\\\/health-implications-of-plastics-in-our-ecosystem\\\/\",\"url\":\"https:\\\/\\\/wp.csiro.au\\\/epws24\\\/health-implications-of-plastics-in-our-ecosystem\\\/\",\"name\":\"Health implications of plastics in our ecosystem - 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